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Skin Science Clinical Peptide Serum bottle with text highlighting its benefits on a white background

Skin Science Repair Serum Ingredients with text labels on a serum drop.

Skin Science Clinical Peptide Serum bottle on a reflective surface with a gradient background

Skin Science Clinical Peptide Serum before and after comparison of skin tone with text indicating improvement.

Skin Science Clinical Peptide Serum before and after comparison in the reduction of fine lines and wrinkles.

Woman holding a Skin Science Clinical Peptide Serum bottle against a beige background

Clinical Peptide Serum

Plumps, smooths, and strengthens for a youthful complexion.

30 ml / 1 oz. fl

Wake up to visibly firmer, smoother, younger-looking skin. This dermatologist-developed overnight serum targets visible signs of aging with 5D Hyaluronic Acid for deep hydration, Niacinamide to refine tone and strengthen the barrier, and Adaptogenic Botanicals to calm stressed skin.

The result: a refreshed, resilient, and renewed complexion by morning.

Save Up To 40% With Automatic Refills!

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60-day money back guarantee

60-Day Money-Back Guarantee

See visible results after 60 days or your money back — even if the bottle’s empty.

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No hidden fees. Free delivery across the US mainland.

Dermatologist Developed

Expertly formulated with scientifically proven actives.

What you'll notice

Week 1

Skin begins to feel deeply hydrated, soothed, and comfortable, with a visibly calmer appearance and reduced dryness.

Week 2-4

Texture looks smoother and more refined. Fine lines appear softened, redness looks reduced, and skin feels stronger and more youthful.

Ongoing Use

Skin remains hydrated and radiant, with visibly softer lines, a more even tone, and a calm, balanced look you’ll love.

a woman's face with a comparison of her skin

Carmen’s Journey | Duration 2 weeks

“This left my skin feeling deeply moisturized and helped smooth out the uneven areas I’ve always struggled with. I wasn’t expecting a big transformation, so the results really surprised me. It’s definitely become one of those products I’d 100% recommend to anyone.”

Kellys’s Journey | Duration 4 weeks

“I’ve been using this serum as part of my routine, and it’s made such a difference. My skin feels more hydrated and has a healthy brightness in the morning. I usually have a hard time with products that contain actives because my skin is so sensitive, but this one hasn’t caused any irritation at all.”

Nicole’s Journey | Duration 8 weeks

“I love this serum. My skin feels more hydrated when I wake up and looks brighter overall. The dark spots on my cheeks have faded too, which I honestly didn’t expect. Since my skin is sensitive, I usually can’t handle products with strong actives, but this one has been gentle and soothing.”

a woman's face with a comparison of the same before and after

Camila's Journey | Duration 1 Month

“I’ve always struggled with dark spots and skin that looked dull. After a month of using this serum, my skin looks brighter and clearer. The spots on my face have begun to fade, and my skin feels smoother with a healthy glow. It’s the first time I can honestly say I’m seeing real results.”

a woman with wrinkles and a few years after her skin

Hannah's Journey | Duration 3 Months

“My skin always looked red, irritated, and tight no matter what I tried. After consistently using this serum, the redness completely calmed down and my skin feels comfortable again. It looks much plumper and healthier. For the first time in a long while, I actually feel good about my skin.”

Jessica's Journey | Duration 6 Weeks

"Six weeks in and my skin looks so much smoother. The rough texture around my cheeks has softened, and overall my skin feels calmer and more balanced. I’ve tried a lot of serums before, but this is the first one that gave me visible results without irritation."

Why It Works

Targeted Hydration in Every Layer

Our Hyaluronic Acid Hydration Boost™ delivers deep, lasting moisture to plump and smooth within the skin’s surface layers.

Repair Without Irritation 

Firming & Smoothing Peptide Complex™ reduces visible signs of aging, improves firmness, and refines texture while keeping skin calm and comfortable.

Strengthened Barrier Support 

Soothing botanicals fortify the skin barrier, calm visible stress, and support its natural renewal.

One formula replaces 3 serums.

Hydrates, smooths, firms, and boosts resilience in a single step, simplifying your routine without compromising results.

Dr. Katherine Mercer MD, FAAD, Board-Certified Dermatologist

"
I often recommend Bakuchiol, Collagen, Niacinamide, and Hyaluronic Acid to support smoother, firmer, more radiant skin. This serum combines them all in a single formula that actually works.
"

Good to know

How to use

Step 1: Prep Your Skin 

Begin with a clean, dry face to ensure optimal absorption of the serum’s active ingredients.

Step 2: Apply Serum

Dispense 2–3 drops of the serum onto your fingertips and gently pat onto your face and neck, avoiding the eye area. Patting rather than rubbing helps the formula absorb evenly.

Step 3: Let It Absorb

Allow 1–2 minutes for the serum to fully absorb into your skin before applying additional products.

Step 4: Seal in Hydration

Follow with Adaptogenic Soothing Cream or Moisture-Locking Face Oil to lock in moisture and support the serum’s repairing benefits overnight.

Our 60 Day Guarantee

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror.

That’s why every purchase is backed by our 60-day money-back guarantee.

If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.

Erykah T.

Verified Purchase

If you have dry skin you need this!

The hydration my skin received after using this for a couple weeks was insane. I love how it smells. I love how it feels. My skin is way more hydrated. I love it so much.

Katelynn A.

This serum is a MUST HAVE!!! 🤩

This overnight skin serum truly feels like my skin is getting a big ol drink of water every night when I apply it and every morning when I wake up, my skin is nice and glowy like I just got home from the medspa. It’s lightweight so it doesn’t have that heavy, greasy feeling yet so effective at the same time. YAY for the power of plants!!! This is definitely a must have in my skincare game from now on!!

Kelly R.

Verified Purchase

My All-Time Favorite Serum!

This Clinical Peptide Serum is an absolute must have! So much goodness in one bottle...Hyaluronic Acid, Bakuchiol AND Niacinamide! My skin has never looked so hydrated and so smooth. I love the way it feels when applied and it has such a wonderful smell! Highly recommend!

What’s inside

Firming & Smoothing Peptide Complex™
Bakuchiol, Niacinamide, and Plant Collagen visibly smooth fine lines, enhance firmness, and refine texture to deliver anti-aging benefits without irritation.
Hyaluronic Acid Hydration Boost™
Five molecular weights of Hyaluronic Acid with Ceramides and Squalane deliver deep, lasting hydration, lock in moisture, and visibly plump the skin for a smoother look.
Redness-Relief Adaptogen Complex™
Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha calms visible redness, reduces signs of stress, and supports the skin’s natural resilience for a balanced, healthy-looking complexion.

Shared by people who tried it

Product FAQs

How long until I see results with the Clinical Peptide Serum?

Most users notice a softer, more hydrated glow after the first few uses. With continued nightly use, skin typically appears smoother, calmer, and more even-toned within 2–4 weeks. The Clinical Peptide Serum is designed to restore and strengthen your skin barrier over time, so consistency is key.

What does the Clinical Peptide Serum do? 

This serum is a barrier-strengthening, recovery-focused treatment designed to hydrate, calm, and support skin overnight. It helps repair dryness, reduce redness, and rebalance stressed or over-exfoliated skin. It’s also the perfect complement to active ingredients like retinol or acids.

Is the Clinical Peptide Serum suitable for all skin types?

Yes, the Clinical Peptide Serum is safe for all skin types, including sensitive, acne-prone, and dry skin. Its minimal, non-comedogenic formula supports hydration and barrier health without clogging pores or causing breakouts.

What makes this different from a typical hydrating serum?

While most hydrating serums focus on water content, this formula does more. It combines barrier-repair lipids, soothing adaptogens, and restorative peptides to actively rebuild and strengthen the skin’s protective layer—not just hydrate it.

Can I use the Clinical Peptide Serum every night?

Absolutely. It’s gentle enough for nightly use, even twice daily if needed. Use it on its own or rotate it with our Overnight Retinol Serum depending on your skin’s needs.

Is the Clinical Peptide Serum safe for pregnancy or breastfeeding?

Yes—this formula contains no retinoids or harsh actives, making it generally safe for pregnancy and breastfeeding. However, we always recommend consulting your doctor before introducing new skincare products during pregnancy or breastfeeding.

What customers are saying

4.69 out of 5

Based on 213 reviews

173

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Customer photos & videos

12/14/2025

10-Day Review

I used this serum every night for 10 days, and I’m honestly so impressed — my skin looks brighter, calmer, and way more hydrated with no makeup on. The redness around my nose is gone, and my hyperpigmentation looks noticeably reduced. I love that it’s cruelty-free, mostly natural, and replaces three products with one easy, luxe night serum.